Although it has been in use for a few decades as an effective treatment for depression, a certain controversial fact will emerge in 2014 that has triggered its ban in several in several countries including the UK.
A 2014 study found that tianeptine is a mu-opioid receptor full agonist. This explains its opioid-like effects which are mostly experienced when taking extremely high doses. [R]
Still, even though it acts on the same receptors, tianeptine is often used together with morphine to prevent respiratory depression associated with opioids. [R]
Some of its antidepressant effects are said to be attributed to the alteration of glutamate receptor activity, namely the AMPA and NMDA receptors and through the release of BDNF (brain-derived neurotrophic factor) which affects neuroplasticity. [R]
Tianeptine also enhances the mesolimbic release of dopamine by potentiating the D2 and D3 receptors. [R]
Depression produces morphological changes in the hippocampus and the amygdala. A 2008 study has proven the efficacy of Tianeptine in preventing chronic stress-induced changes in the brain and blocks the effects of stress on synaptic plasticity in the hippocampus and prefrontal cortex. [R]
Studies have found that people who undertook treatment for depression were less likely to relapse. [R]
Also, Tianeptine helps in preventing the stress-induced impairment of memory in people suffering from depression. It is as effective in treating depression as other common SSRI’s (selective serotonin reuptake inhibitors) such as fluoxetine, with significantly fewer side effects.
Tianeptine is effective in relieving the symptoms of depression, as well as preventing its consequences on the body. It can be used to treat other mood disorders and can also be used for the treatment of anxiety.
When thinking of Tianeptine sulfate vs sodium, choosing the right one for you depends on several factors.
Some prefer one over the other according to several factors: onset, duration, bioavailability, taste and degradation rate.
Onset/Duration – Tianeptine sulfate takes a few hours to kick in, but will last a whole day, thus only necessitating a single daily dose. Tianeptine sodium kicks in faster and is three to four times more potent. Also, it should be taken four times a day for its effects to be continuously felt.
Bioavailability – Tianeptine sulfate has a higher solubility in water, thus increasing its bioavailability.
Stability – Tianeptine sodium is known to rapidly degrade once the seal has been opened due to moisture and exposure to light.
Taste – Tianeptine sulfate is almost insipid, while tianeptine sulfate has been reported to have a bitter taste
From a medical point of view, tianeptine sulfate is better for somebody undergoing treatment because the risk of ineffective treatment cause by skipping doses significantly decreases when only one dose/day is needed.
Also, tianeptine sodium is reported to provide a noticeable increase in energy and motivation. Tianeptine sulfate is said to not be as energizing, which can partly be attributed to the increased dosage that is needed and its slow onset.
For tianeptine sodium, dosage lies around 15 mg – 100 mg range, with 15 mg being the standard dose one would take to feel the effects.
A 100 mg dose of tianeptine sodium would most likely cause opioid-like effects.
For tianeptine sulfate, dosage varies from individual to individual and reports vary across the web. The typical dose is 40 mg, yet everyone reacts differently.
Tianeptine sulfate isn’t intended to be instantly felt and is usually prescribed by doctors for long-term treatment of depression or mood-related disorders.
Obviously, oral administration should be the only considered
Whatever you do, avoid sublingual tianeptine administration. Tianeptine sodium will cause skin-peeling in the mouth, while tianeptine sulfate may cause tongue infections, which could be attributed to disturbed acid balance which, in turn, allows yeast to grow.
Smoking or snorting tianeptine, whether it’s in sodium or sulfate form is something that naive teenagers would even think of doing. Still, it was worth mentioning because the potential for abuse is real and must be discouraged.
If you’re wondering whether you should be using tianeptine with or without food, then you should consider taking it some 20 minutes before your meal to ensure that it gets digested properly.
Also, you should not take more than 100 milligrams at once or 300 milligrams over the course of a day.
Doctors worldwide prescribe Tianeptine for depression, anxiety and other mood disorders.
Tianeptine offers a variety of benefits for healthy people as well, including:
Tianeptine can be very beneficial for people who are suffering from anxiety disorders. There are lots of reports on Reddit, Quora and popular health-related forums such as Longecity or Drugs-forum regarding the efficacy of tianeptine in warding off negative thoughts, anhedonia, memory problems, depersonalization or derealization.
Tianeptine sodium is the preferred form used by people recreationally (for the “tianeptine high”).
Of course, you can use tianeptine sulfate recreationally as well. However, the dosage is higher and you’ll have to wait a few hours to feel the effects.
The tianeptine high is described as a pleasant mood lift, lowered anxiety, increased drive to do things.
Users have also reported that tianeptine produces a state of wakefulness, mental clarity and a deep sense of well-being.
Effects increase as dosage increases to the point that some users have described it as being similar to MDMA or Phenibut.
It should be noted that there are mixed reviews regarding what some would call “tianeptine euphoria”.
Users have reported feeling subtle effects in low doses, while the opiate-like effects surfacing only when taking high doses.
Tianeptine also causes a numbing of the libido, even in moderate doses.
Tianeptine is generally safe to use, although it can cause a series of side effects for some users:
There are no scientific studies regarding the long-term effects of tianeptine use. The fact that it is being prescribed for the treatment of depression should hint at its relative safety, even though specific studies regarding this aspect haven’t been conducted.
Tolerance sets in after taking it regularly, which also includes tolerance to therapeutic benefits. It takes around 3-7 days for tolerance to be reduced to half and 1-2 weeks to be back at baseline. Given its similarity in action to opioids or tricyclic antidepressants, tianeptine may affect the liver if consuming it long-term.
Constipation is quite normal when taking tianeptine. Coffee mixed with coconut oil is a good remedy tianeptine constipation.
Tianeptine withdrawal may occur, though it is unlikely if the dosage is kept in check. Addiction could set in if one were to take large doses frequently for an extended period of time.
Tianeptine is far from being an opiate if taken in moderate doses.
User reports spread across the web are mixed when it comes to overall satisfaction.
While it does indeed act similarly to an opiate due to its action on the mu-opioid receptor, it’s far from being an actual opiate. This may lead to disappointments from users who are looking to “get messed up”.
Those who are taking it for what it’s actually good at (as a nootropic), are quite satisfied with its effects, particularly with its mood-lifting and motivation-enhancing properties.
There are also some Reddit users who regard the lack of scientific studies a good enough reason to avoid constantly using tianeptine.
Tianeptine can be stacked with other supplements to enhance certain effects or decrease (take the edge off of) other side effects.
Some people even use tianeptine sulfate and sodium together to make the overall effect longer-lasting. This counteracts the short-lasting effects of tianeptine sodium.
Phenibut is an anxiolytic with nootropic properties.
Both are slightly stimulating in small doses and highly sedating when taking large doses.
Motivation, focus, mood and wakefulness are increased when taking low doses of each.
The two can be substituted with each other to avoid tolerance build-up.
Kratom is a herb that grows in Southeast Asia and produces a variety of effects.
Because Kratom strains vary so much in their effects, this herb may be taken for enhanced stimulation or sedation.
Certain strains, such as Maeng Da are stimulating and will increase the nootropic properties of tianeptine.
Red strains, particularly Red Bali, produces sedating effects. These ones will increase the feelings of contentment associated with opiates.
Coconut oil is useful to prevent potential constipation caused by tianeptine.
A tasty and effective way to ingest coconut oil for its laxative effects is by combining it with caffeine.
Caffeine also has laxative and nootropic effects.
This way, you would be getting an enhanced experience together with an “easy-to-go” way to the bathroom.
Tianeptine’s effects on dopamine receptors indirectly result in acetylcholine depletion.
This may lead to the user experiencing headaches.
Fortunately, this can easily be remedied by eating foods high in choline such as eggs or by supplementing with choline or citicholine.
Tianeptine capsules versus tianeptine powder is a matter of preference for nootropic users.
Tianeptine that comes in capsule form is already weighed and ready to ingest.
Thus, it’s easy to know how much you’re taking without the use of anything else.
Tianeptine in its powder form is almost always cheaper if considering how many milligrams you get for your money.
It may be challenging to weigh and ingest, though.
You would need a milligram scale for precision and some capsules to avoid tasting the substance.
There are many fake vendors active across the web. Only buy tianeptine from popular vendors.
Given the reports spread across the web about people not feeling nothing from tianeptine, it’s always good to stay on the safe side and only buy tianeptine online from reputable online nootropic vendors.
One such vendor is Nootropics.com. You can buy tianeptine at really low prices, along with other popular nootropics including, but not limited to Adrafinil, Noopept, L-Theanine or Phenibut.