The modafinil vs armodafinil battle rages on…
Modafinil is the most popular cognitive enhancer. Armodafinil is “its little cousin”. Biohackers are debating whether one is better than the other…
In theory, armodafinil is “the new and improved” version of Modafinil. However, armodafinil does have its pros and cons (as users point out).
UPDATE (January 2020): This is an old post that dates from 2017. I’ve decided to provide you with a better version that will help you understand modafinil, armodafinil and the link between them.
I did say they’re cousins, but let’s get a bit more “technical” with the explanations. It’s not that hard anyway.
Modafinil is made of three key elements: the S-enantiomer, the R-enantiomer and modafinilic acid. (Source)
The R-enantiomer is responsible for the majority of cognitive benefits. Therefore, scientists decided that it’s a good idea to isolate the compound. In 1990, armodafinil was first synthesized and in 2007, the FDA approved it as a prescription drug. (Source)
Doctors commonly prescribe modafinil as Provigil and armodafinil as Nuvigil. Still, the cost can get very high if your insurance doesn’t cover it. You can also buy modafinil and armodafinil from online vendors for a fraction of the price. Here’s a comprehensive guide on the Modafinil online world, seen from a US perspective.
Modafinil vs armodafinil.. A difficult choice for many and totally understandable. The two smart drugs are widely known for their cognitive-boosting effects.
Both are part of the eugeroic class of drugs, also known as wakefulness-promoting agents. Both are prescribed to those who suffer from narcolepsy, sleep apnea and work-shift disorder. [R]
After being approved by the FDA, some further research was made regarding other uses. Results showed that both drugs can be used to treat many other conditions. These include ADHD, depression, bipolar disorder, Parkinson’s disease and other disorders that cause fatigue. [R][R][R]
Modafinil and armodafinil are labeled as smart-drugs, yet they also fall under the nootropics category. People all over the world use them for cognitive enhancement, to combat fatigue and increase energy levels.
The main difference between the two is in their molecular structure. Modafinil is made of two enantiomers, the R-enantiomer and the S-enantiomer. Armodafinil is made of one enantiomer, the more potent one.
The main physical effects of modafinil and armodafinil include:
Modafinil encourages physical movement and other activities such as sports, exercising at the gym or running.
Armodafinil has the same stimulating properties that encourage physical and social activities. It’s basically a newer and improved version of modafinil.
Studies have reported that armodafinil’s effects are slightly more obvious than the ones experienced on modafinil. Furthermore, the half-life lasts 12 hours, whilst the half-life of armodafinil lasts 15 hours.
Both drugs increase the production of dopamine, norepinephrine and orexin. Also, modafinil and armodafinil decrease the production of the GABA hormone which leads to increased histamine production. [R]
The main cognitive effects of modafinil are as follows:
Wakefulness. Modafinil makes you feel wide awake even when taking a small dose. Also, studies have shown that it restores cognitive efficacy in sleep-deprived individuals.
An increased desire to perform tasks. Another defining benefit of modafinil is the increase in drive and motivation. It’s effective in making boring tasks more fun and difficult ones easier to accomplish.
Focus enhancement. Your peripheral vision becomes less focus and whatever you’re focusing on gains increased importance. It’s quite difficult to describe. Some people regard the feeling like a “tunnel-like vision”.
Thought acceleration and organization. Akin to caffeine, modafinil speeds up thought process and organization.
Improved mood. Modafinil has a minor effect on mood. Still, people generally don’t feel like socializing on it.
Increased music appreciation. The focus experienced on modafinil is also reflected in one’s understanding of music.
Armodafinil has the same cognitive effects as modafinil. Still, anecdotal reports suggest that armodafinil is more effective with regards to focus and wakefulness.
Also, some users have reported that modafinil has a greater impact on one’s capacity to feel emotions.
Armodafinil is about 1.33 times more potent than modafinil. There are studies and user reports to back up that fact.
The first aspect users have noticed is that armodafinil has longer-lasting effects compared to modafinil. That’s because armodafinil has a longer half-life than modafinil. [R]
(The half-life of a substance is the period of time needed for the substance to leave your body.)
One study has shown that armodafinil and modafinil have different pharmacokinetic properties. This results in armodafinil’s increased effectiveness in the late stages of its effects.
Furthermore, anecdotal reports suggest that armodafinil favors focus and memory enhancement, but it also comes with heightened feelings of anxiety.
One Reddit user cleverly stated that modafinil is overall “better” and armodafinil is more “effective”. Modafinil has a more prominent influence on mood and motivation than armodafinil. Anecdotal reports suggest that the latter is better for focus and productivity.
All in all, the two are quite similar in terms of effects. Aside from treating sleep disorders, ADHD or depression, modafinil and armodafinil have other uses which have stolen the spotlight:
Enhanced and longer study periods. Modafinil is very popular among students who are keen on all-nighters. Also, both smart drugs increase reading speed and allow the user to focus for extended periods of time.
Increased productivity and willingness to work. Modafinil and armodafinil are great for prolonged periods of work. Coders, bankers and doctors benefit from the “tunnel-like” vision and wakefulness produced by the two smart drugs.
Better performance in sports and fitness. The two smart drugs increase endurance to physical effort. Also, both are effective “laziness-relievers”.
Improved reaction times for pro gamers. Of course, this is useful for a whole lot of other activities. The state of non-agitated vigilance favors activities that necessitate fast reaction times.
Modafinil is considered “the world’s first safe smart drug” and armodafinil is the cleaner version. Still, the two have some mild side effects that typically increase with dosage:
Fast heart rate;
Users have reported drastic changes in social comfort zone. Some have reported feeling impatient or nervous when talking to people.
Modafinil and armodafinil have no lethal dose. Overdosing usually leads to nausea, dizziness and confusion. There are no registered deaths based on modafinil overdosing.
Armodafinil has roughly the same side-effects as modafinil. Due to having a longer half-life, one might have more trouble falling asleep at night. You can get around this by taking it early, exercising during the day and eating a heavy meal at night.
Green tea and black tea are popular to take together with modafinil and armodafinil. Both contain caffeine and l-theanine, which can greatly enhance the experience without producing anxiety. The key is to take small sips over an extended period of time.
Some users also use drugs from the ”racetam” group such as piracetam, levetiracetam and oxiracetam to gain an increase in focus, stimulation and thought-organization by consuming modafinil or armodafinil.
Armodafinil is more potent than modafinil, so it requires smaller doses for it to work. The usual dose of modafinil is 200 mg/day.
Some prefer to split the typical Modalert pill into two halves. Others prefer taking the whole pill all at once for an intense feeling of wakefulness, stimulation and focus.
The regular dose of armodafinil is 150 mg once a day for the exact same results as for modafinil.
That doesn’t mean that armodafinil or modafinil shouldn’t be taken in lower doses. In fact, it’s recommended that one does so in order to find the optimal dose.
You would be surprised, but some people make do with 25 mg – 50 mg of either armodafinil or modafinil. The optimal dosage largely depends on the reasons for using it.
For example, someone who’s working long shifts may find low doses insufficient to prevent sluggishness caused by lack of sleep. However, a student looking for extra focus without being sleep-deprived may reap the same benefits from a lower dose.
Modafinil was first manufactured in the ’70s by neurophysiologist Michel Jouvet, in collaboration with Lafon Laboratories. During that period, other benzhydryl sulfinyl compounds, such as adrafinil, were invented. Adrafinil was first given as an experimental alternative for the treatment of narcolepsy in 1986.
Modafinil, a purer version of adrafinil and its main active substance, was first prescribed in 1994 in France as Modiodal. In 1998, modafinil was approved by the Food and Drug Administration in the US and prescribed for narcolepsy. [R] The year 2003 saw its approval for the treatment of sleep-related disorders. In December 2002, modafinil was also approved in the UK.
In the USA, Cephalon Inc. is responsible for marketing modafinil. It had originally leased the right from Lafon Laboratories. In 2001, Cephalon Inc. purchased Lafon. In 2007, the company started marketing armodafinil, though protracted patent litigation saw the rise of other generic versions of modafinil in the USA in 2012.
Cephalon Inc. knew that they were standing on a gold mine. Dr. Frank Baldino, the company founder, famously stated that “There are no warts on this drug, the only question is how big we can make it”.
The company’s global business conduct produced huge profits from modafinil sales. In 2008, the revenues earned from Provigil were reported to have exceeded $1 billion.
Still, the patents were set to expire and the FDA granted Mylan and other companies the rights to manufacture generic modafinil and armodafinil.
Modafinil is available under the following brand names:
Armodafinil is available under the following brand names:
By far, the most popular brands of modafinil and armodafinil are Waklert, Modalert, Artvigil and Modvigil.
As stated above, multiple companies produce generic modafinil and armodafinil. The prescription-based tablets (Provigil or Nuvigil, to name a few) are a lot more expensive.
Pharmacies prescribe generic modafinil and armodafinil produced in the USA. However, the cost is extremely high if it’s not compensated.
Sun Pharmaceuticals is an FDA-approved producer of modafinil and armodafinil. Most online pharmacies collaborate with this company.
Sun Pharmaceuticals manufactures modafinil as Modalert and armodafinil as Waklert. Modalert and Waklert are the most popular brands of the two corresponding smart drugs.
Provigil 200mg: $44,39 per pill.
Nuvigil 150mg (discounted): $22,12 per pill.
The government doesn’t always pay for treatment. Hence, the average American or Brit can’t afford to pay this much for treatment.
Modalert and Waklert are available online for a fraction of the cost. The price per pill when ordering 30 pills vs 300 pills is as follows:
Modalert 200mg: $2,17 – $0,97 per pill.
Waklert 200mg: $2,33 – $0,98 per pill.
Online pharmacies usually offer discounts when paying with Bitcoin (10-20%). That’s because payments with PayPal or credit card imply extra processing fees.
DrModafinil.com also offers 30 bonus pills for orders above 100 pills. Hence, the cost per pill can get lower than mentioned.
A rule of thumb for most products is: “the more you pay, the more you can expect”. That’s not the case in the modafinil market.
200 milligrams of Provigil vs 200 milligrams of Modalert are one and the same.
The same principle applies to Waklert vs Nuvigil.
Of course, you can go to your doctor and ask for a prescription. You should be honest, though… you don’t want to misinform your physician.
If you’re suffering from narcolepsy or obstructive sleep apnea, you can easily obtain a prescription.
The doctor may prescribe modafinil or armodafinil if you’re having difficulty concentrating at work. Also, your entrepreneurial endeavors may cause stress and brain fog.
Other proven benefits that might make you eligible for a prescription include depression or ADHD. Doctors aren’t authorized to prescribe either of the smart drugs for those issues.
Still, you can always try. Just don’t make things up.
Choosing between modafinil and armodafinil is a subjective matter. The choice depends on your expectations and purpose.
Modafinil shows higher popularity among users because of its creativity boosting effect, which some say is absent in armodafinil.
Another characteristic that contributes to people’s preference for modafinil is its half-life. The effects of modafinil last for about 8 to 10 hours, whereas armodafinil provides a total of 12 to 14 hours of stimulation.
DrModafinil.com is an Armodafinil and Modafinil vendor with competitive prices and fast delivery times. This vendor ships from three places in the world. Also, their customer support is very responsive.